Proteomics

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Lapatinib action and resistance in breast cancer


ABSTRACT: We used an established cell line model of lapatinib resistance and employed explorative mass spectrometry to profile the proteome, kinome and phosphoproteome changes in an effort to systematically investigate initial inhibitor response and concomitant kinome reprogramming and signaling rewiring in resistance. Experiments were performed in three biological replicates

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Breast Cancer

SUBMITTER: Benjamin Ruprecht  

LAB HEAD: Simone Lemeer

PROVIDER: PXD004981 | Pride | 2017-02-27

REPOSITORIES: Pride

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