Proteomics,Multiomics

Dataset Information

0

Utx interactome in mouse myeloid progenitor cells


ABSTRACT: Immunoprecipitation of Utx followed by mass spectrometry analysis to identify Utx binding partners in mouse myeloid progenitor cells.

OTHER RELATED OMICS DATASETS IN: PRJNA393986PRJNA342026GSE86490

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Common Myeloid Progenitor

DISEASE(S): Leukemia

SUBMITTER: Hendrik Weisser  

LAB HEAD: Jyoti Sharma Choudhary

PROVIDER: PXD005011 | Pride | 2018-04-30

REPOSITORIES: Pride

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Publications


The histone H3 Lys27-specific demethylase UTX (or KDM6A) is targeted by loss-of-function mutations in multiple cancers. Here, we demonstrate that UTX suppresses myeloid leukemogenesis through noncatalytic functions, a property shared with its catalytically inactive Y-chromosome paralog, UTY (or KDM6C). In keeping with this, we demonstrate concomitant loss/mutation of KDM6A (UTX) and UTY in multiple human cancers. Mechanistically, global genomic profiling showed only minor changes in H3K27me3 but  ...[more]

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