Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA343729
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Hepatocyte, Cell Culture
SUBMITTER: Paul Grimsrud
LAB HEAD: Matthew D. Hirschey
PROVIDER: PXD005040 | Pride | 2016-12-22
REPOSITORIES: Pride
McDonnell Eoin E Crown Scott B SB Fox Douglas B DB Kitir Betül B Ilkayeva Olga R OR Olsen Christian A CA Grimsrud Paul A PA Hirschey Matthew D MD
Cell reports 20161101 6
Cells integrate nutrient sensing and metabolism to coordinate proper cellular responses to a particular nutrient source. For example, glucose drives a gene expression program characterized by activating genes involved in its metabolism, in part by increasing glucose-derived histone acetylation. Here, we find that lipid-derived acetyl-CoA is a major source of carbon for histone acetylation. Using <sup>13</sup>C-carbon tracing combined with acetyl-proteomics, we show that up to 90% of acetylation ...[more]