Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Colon
DISEASE(S): Inflammatory Bowel Disease
SUBMITTER: Amanda Starr
LAB HEAD: Daniel Figeys
PROVIDER: PXD005086 | Pride | 2018-11-06
REPOSITORIES: Pride
Starr Amanda E AE Deeke Shelley A SA Ning Zhibin Z Chiang Cheng-Kang CK Zhang Xu X Mottawea Walid W Singleton Ruth R Benchimol Eric I EI Wen Ming M Mack David R DR Stintzi Alain A Figeys Daniel D
Gut 20160523 9
<h4>Objective</h4>Accurate differentiation between Crohn's disease (CD) and UC is important to ensure early and appropriate therapeutic intervention. We sought to identify proteins that enable differentiation between CD and UC in children with new onset IBD.<h4>Design</h4>Mucosal biopsies were obtained from children undergoing baseline diagnostic endoscopy prior to therapeutic interventions. Using a super-stable isotope labeling with amino acids in cell culture (SILAC)-based approach, the proteo ...[more]