Differential signaling through p190 and p210 BCR-ABL fusion proteins revealed by interactome and phosphoproteome analysis
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): B Cell
DISEASE(S): Acute Leukemia
SUBMITTER: 
Akhilesh Pandey
LAB HEAD: Akhilesh Pandey
PROVIDER: PXD005209 | Pride | 2017-03-20
REPOSITORIES: Pride
Publications
Differential signaling through p190 and p210 BCR-ABL fusion proteins revealed by interactome and phosphoproteome analysis.
Cutler J A JA Tahir R R Sreenivasamurthy S K SK Mitchell C C Renuse S S Nirujogi R S RS Patil A H AH Heydarian M M Wong X X Wu X X Huang T-C TC Kim M-S MS Reddy K L KL Pandey A A
Leukemia 20170217 7
Two major types of leukemogenic BCR-ABL fusion proteins are p190<sup>BCR-ABL</sup>and p210<sup>BCR-ABL</sup>. Although the two fusion proteins are closely related, they can lead to different clinical outcomes. A thorough understanding of the signaling programs employed by these two fusion proteins is necessary to explain these clinical differences. We took an integrated approach by coupling protein-protein interaction analysis using biotinylation identification with global phosphorylation analys ...[more]
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