Retinal proteomic profiling in the course of experimental glaucoma
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap XL
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Layer Of Retina, Retina
DISEASE(S): Glaucoma
SUBMITTER: 
Fabian Anders
LAB HEAD: PD Dr. Verena Prokosch
PROVIDER: PXD005258 | Pride | 2017-04-11
REPOSITORIES: Pride
Publications
Intravitreal injection of β-crystallin B2 improves retinal ganglion cell survival in an experimental animal model of glaucoma.
Anders Fabian F Teister Julia J Liu Aiwei A Funke Sebastian S Grus Franz H FH Thanos Solon S von Pein Harald D HD Pfeiffer Norbert N Prokosch Verena V
PloS one 20170406 4
Purpose of this study was to investigate firstly specific proteomic changes within the retina in the course of an animal glaucoma model and to identify secondly new approaches for neuroprotective, therapeutic options in glaucoma by addressing those specific changes. Intraocular pressure was elevated through cauterization of episcleral veins in adult Sprague Dawley rats. Molecular and morphological changes were surveyed using mass spectrometry, optical coherence tomography as well as immunohistoc ...[more]
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