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Quantitative multiplex proteomics of Taenia solium cysts

ABSTRACT: Proteome comparision of T. solium cysts obtained from the skeletal muscle and the central nervous systema of infected pig

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Taenia Solium (pork Tapeworm)

SUBMITTER: José Navarrete-Perea

LAB HEAD: Juan Pedro Laclette

PROVIDER: PXD005270 | Pride | 2017-10-09

REPOSITORIES: Pride

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Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.

Navarrete-Perea José J Isasa Marta M Paulo Joao A JA Corral-Corral Ricardo R Flores-Bautista Jeanette J Hernández-Téllez Beatriz B Bobes Raúl J RJ Fragoso Gladis G Sciutto Edda E Soberón Xavier X Gygi Steven P SP Laclette Juan P JP

PLoS neglected tropical diseases 20170925 9

In human and porcine cysticercosis caused by the tapeworm Taenia solium, the larval stage (cysts) can infest several tissues including the central nervous system (CNS) and the skeletal muscles (SM). The cyst's proteomics changes associated with the tissue localization in the host tissues have been poorly studied. Quantitative multiplexed proteomics has the power to evaluate global proteome changes in response to different conditions. Here, using a TMT-multiplexed strategy we identified and quant ...[more]

PMID: 28945737

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