Proteomics,Multiomics

Dataset Information

0

Global functional impacts of Campylobacter jejuni stress induced by exposure to deoxycholate


ABSTRACT: Comparison of the Campylobacter jejuni NCTC 11168 proteome in MH media in the presence and absence of Deoxycholate

OTHER RELATED OMICS DATASETS IN: GSE89641PRJNA352929

INSTRUMENT(S): Q Exactive

ORGANISM(S): Campylobacter Jejuni

SUBMITTER: Matthew Monroe  

LAB HEAD: Joshua Adkins

PROVIDER: PXD005306 | Pride | 2017-11-21

REPOSITORIES: Pride

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Publications

The food-borne pathogen Campylobacter jejuni responds to the bile salt deoxycholate with countermeasures to reactive oxygen species.

Negretti Nicholas M NM   Gourley Christopher R CR   Clair Geremy G   Adkins Joshua N JN   Konkel Michael E ME  

Scientific reports 20171113 1


Bile plays an important role in digestion, absorption of fats, and the excretion of waste products, while concurrently providing a critical barrier against colonization by harmful bacteria. Previous studies have demonstrated that gut pathogens react to bile by adapting their protein synthesis. The ability of pathogens to respond to bile is remarkably complex and still incompletely understood. Here we show that Campylobacter jejuni, a leading bacterial cause of human diarrheal illness worldwide,  ...[more]

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