Delta-like ligand 4-Notch signaling inhibition regulates pancreatic islet function and insulin secretion

ABSTRACT: Dll4-Notch signaling is required for cell fate decisions and neoplasias. However, emerging evidence suggests a role for Dll4-Notch signaling in metabolic and immune diseases. To date, there is no evidence of a direct effect of Dll4-Notch signaling inhibition on pancreatic islet function and insulin secretion.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Antigoni Manousopoulou  

LAB HEAD: Spiros D. Garbis

PROVIDER: PXD005333 | Pride | 2018-08-13

REPOSITORIES: Pride