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Delta-like ligand 4-Notch signaling inhibition regulates pancreatic islet function and insulin secretion

ABSTRACT: Dll4-Notch signaling is required for cell fate decisions and neoplasias. However, emerging evidence suggests a role for Dll4-Notch signaling in metabolic and immune diseases. To date, there is no evidence of a direct effect of Dll4-Notch signaling inhibition on pancreatic islet function and insulin secretion.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Antigoni Manousopoulou

LAB HEAD: Spiros D. Garbis

PROVIDER: PXD005333 | Pride | 2018-08-13

REPOSITORIES: Pride

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Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion.

Billiard Fabienne F Karaliota Sevasti S Wang Bei B Stellas Dimitrios D Serafimidis Ioannis I Manousopoulou Antigoni A Koutmani Yiassemi Y Ninou Elpiniki E Golubov Jacquelynn J DaNave Amanda A Tsakanikas Panagiotis P Xin Yurong Y Zhang Wen W Sleeman Matthew M Yancopoulos George D GD Murphy Andrew J AJ Garbis Spiros D SD Karalis Katia K Skokos Dimitris D

Cell reports 20180128 4

Although Notch signaling has been proposed as a therapeutic target for type-2 diabetes, liver steatosis, and atherosclerosis, its direct effect on pancreatic islets remains unknown. Here, we demonstrated a function of Dll4-Notch signaling inhibition on the biology of insulin-producing cells. We confirmed enhanced expression of key Notch signaling genes in purified pancreatic islets from diabetic NOD mice and showed that treatment with anti-Dll4 antibody specifically abolished Notch signaling pat ...[more]

PMID: 29386132

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