Proteomics

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Anti-Warburg effect elicited by mitochondrial biogenesis drives differentiation of glioblastoma cells into astroglial cells

ABSTRACT: Glioblastoma (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed to be potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we established an induced differentiation model of GBM using cAMP activators, which specifically directed GBM into astroglia. We want to use transcriptomic and proteomic analyses to uncover the central regulators of induced differentiation in solid tumor.

OTHER RELATED OMICS DATASETS IN: PRJNA353078

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Cell Culture

DISEASE(S): Brain Cancer

SUBMITTER: Yizhao Luan  

LAB HEAD: Guangmei Yan

PROVIDER: PXD005334 | Pride | 2017-01-17

REPOSITORIES: Pride

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Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we established an induced differentiation model of GBM using cAMP activators that specifically directed GBM differentiation into astroglia. Transcriptomic and proteomic analyses revealed that oxidative phosphorylation and mitochondrial biogenesis are involved in  ...[more]

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