Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Rectum, Colonic Cancer Cell Line, Colon, Rectal Cancer Cell Line
DISEASE(S): Rectum Cancer,Colon Cancer
SUBMITTER: Martin Frejno
LAB HEAD: Bernhard Kuster
PROVIDER: PXD005355 | Pride | 2017-12-12
REPOSITORIES: Pride
Frejno Martin M Zenezini Chiozzi Riccardo R Wilhelm Mathias M Koch Heiner H Zheng Runsheng R Klaeger Susan S Ruprecht Benjamin B Meng Chen C Kramer Karl K Jarzab Anna A Heinzlmeir Stephanie S Johnstone Elaine E Domingo Enric E Kerr David D Jesinghaus Moritz M Slotta-Huspenina Julia J Weichert Wilko W Knapp Stefan S Feller Stephan M SM Kuster Bernhard B
Molecular systems biology 20171103 11
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome-guided pre-clinical drug sensitivity studies are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of > 10,000 proteins using mass spectrometry. Integration with proteomes of 90 CRC patients and matched transcriptomics data defined integrated CRC subtypes, highlighting cell lines representative of each tumo ...[more]