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THE ATHEROMA PLAQUE SECRETOME STIMULATES THE MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS EX VIVO

ABSTRACT: in this study we evaluated the initial response promoted by the atherosclerotic plaque (AP) secreted factors over healthy endothelial progenitor cells (EPCs), in order to understand the mechanisms underlying the neovascularization and vascular remodeling properties assigned to these cells and to use them as cell therapy in cardiovascular diseases.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Endothelial Cell

SUBMITTER: Maarten Altelaar

LAB HEAD: Maarten Altelaar

PROVIDER: PXD005465 | Pride | 2018-10-02

REPOSITORIES: Pride

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The atheroma plaque secretome stimulates the mobilization of endothelial progenitor cells ex vivo.

Vega Francisco M FM Gautier Violette V Fernandez-Ponce Cecilia M CM Extremera M J MJ Altelaar A F M AFM Millan Jaime J Tellez Juan C JC Hernandez-Campos Jose A JA Conejero Rosario R Bolivar Jorge J Pardal Ricardo R Garcia-Cózar Francisco J FJ Aguado Enrique E Heck Albert J R AJR Duran-Ruiz Mª Carmen MC

Journal of molecular and cellular cardiology 20170220

Endothelial progenitor cells (EPCs) constitute a promising alternative in cardiovascular regenerative medicine due to their assigned role in angiogenesis and vascular repair. In response to injury, EPCs promote vascular remodeling by replacement of damaged endothelial cells and/or by secreting angiogenic factors over the damaged tissue. Nevertheless, such mechanisms need to be further characterized. In the current approach we have evaluated the initial response of early EPCs (eEPCs) from healthy ...[more]

PMID: 28223221

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