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MEIOC interacting proteins during meiotic prophase I

ABSTRACT: The meiosis-specific chromosomal events of homolog pairing, synapsis, and recombination occur over an extended meiotic prophase I. In this study, we show that, in mice, maintenance of an extended meiotic prophase I requires the gene Meioc, a germ-cell specific factor conserved in most metazoans. Using immunoprecipitation and quantitative mass spectrometry, we identify proteins that interact with MEIOC in the mouse germ line.

OTHER RELATED OMICS DATASETS IN: PRJNA380166GSE90702PRJNA355552

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Epithelial Cell

SUBMITTER: Amanda Del Rosario

LAB HEAD: Amanda Del Rosario

PROVIDER: PXD005473 | Pride | 2017-03-27

REPOSITORIES: Pride

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Meioc maintains an extended meiotic prophase I in mice.

Soh Y Q Shirleen YQS Mikedis Maria M MM Kojima Mina M Godfrey Alexander K AK de Rooij Dirk G DG Page David C DC

PLoS genetics 20170405 4

The meiosis-specific chromosomal events of homolog pairing, synapsis, and recombination occur over an extended meiotic prophase I that is many times longer than prophase of mitosis. Here we show that, in mice, maintenance of an extended meiotic prophase I requires the gene Meioc, a germ-cell specific factor conserved in most metazoans. In mice, Meioc is expressed in male and female germ cells upon initiation of and throughout meiotic prophase I. Mouse germ cells lacking Meioc initiate meiosis: t ...[more]

PMID: 28380054

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