Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Jurkat Cell
DISEASE(S): Human Immunodeficiency Virus Infectious Disease
SUBMITTER: Clare Jolly
LAB HEAD: Clare Jolly
PROVIDER: PXD005658 | Pride | 2022-02-28
REPOSITORIES: Pride
Len Alice C L ACL Starling Shimona S Shivkumar Maitreyi M Jolly Clare C
Cell reports 20170101 4
HIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways, we developed an approach to analyze the phosphoproteome in infected and uninfected mixed-population T cells using differential metabolic labeling and mass spectrometry. We discovered HIV-1-induced activation of signaling networks during viral spread encompassing over 200 cellular proteins. Strikingly, pathways downstr ...[more]