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TRAIL-induced cancer secretome

ABSTRACT: To comprehensively determine which factors are secreted by cancer cells upon TRAIL stimulation, we conducted an unbiased mass spectrometric analysis of TRAIL’s secretome in resistant A549 cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell Of Lung

DISEASE(S): Non-small Cell Lung Carcinoma

SUBMITTER: Silvia Surinova

LAB HEAD: Silvia Surinova

PROVIDER: PXD005664 | Pride | 2017-12-19

REPOSITORIES: Pride

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The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2.

Hartwig Torsten T Montinaro Antonella A von Karstedt Silvia S Sevko Alexandra A Surinova Silvia S Chakravarthy Ankur A Taraborrelli Lucia L Draber Peter P Lafont Elodie E Arce Vargas Frederick F El-Bahrawy Mona A MA Quezada Sergio A SA Walczak Henning H

Molecular cell 20170201 4

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known for specifically killing cancer cells, whereas in resistant cancers, TRAIL/TRAIL-R can promote metastasis via Rac1 and PI3K. It remains unknown, however, whether and to what extent TRAIL/TRAIL-R signaling in cancer cells can affect the immune microenvironment. Here we show that TRAIL-triggered cytokine secretion from TRAIL-resistant cancer cells is FADD dependent and identify the TRAIL-induced secretome to drive monoc ...[more]

PMID: 28212753

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BID is critical for IFN-alpha-induced cell death

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VAMP7-dependent autophagic secretion allows for axonal resilience in growth restricting conditions.VAMP7-dependent autophagic secretion allows for axonal resilience in growth restricting conditions.

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