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Mouse Liver LC-MSMS - Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation

ABSTRACT: Mice were starved overnight and divided into three groups: a) refed for 30 min b) caged food (not able to reach, but to smell and see food) c) further fasted. The aim of the study was to determine phosphorylation events in the liver in response to visual exposure of food. See more details in the manuscript and Supplementary Tables.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Hendrik Nolte

LAB HEAD: Marcus Krueger

PROVIDER: PXD005681 | Pride | 2018-10-31

REPOSITORIES: Pride

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Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.

Brandt Claus C Nolte Hendrik H Henschke Sinika S Engström Ruud Linda L Awazawa Motoharu M Morgan Donald A DA Gabel Paula P Sprenger Hans-Georg HG Hess Martin E ME Günther Stefan S Langer Thomas T Rahmouni Kamal K Fenselau Henning H Krüger Marcus M Brüning Jens C JC

Cell 20181101 5

Adaptation of liver to the postprandial state requires coordinated regulation of protein synthesis and folding aligned with changes in lipid metabolism. Here we demonstrate that sensory food perception is sufficient to elicit early activation of hepatic mTOR signaling, Xbp1 splicing, increased expression of ER-stress genes, and phosphatidylcholine synthesis, which translate into a rapid morphological ER remodeling. These responses overlap with those activated during refeeding, where they are mai ...[more]

PMID: 30445039

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