Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Lymphoblast
DISEASE(S): Burkitt Lymphoma
SUBMITTER: Niclas Olsson
LAB HEAD: Joshua E Elias
PROVIDER: PXD005704 | Pride | 2017-03-27
REPOSITORIES: Pride
Khodadoust Michael S MS Olsson Niclas N Wagar Lisa E LE Haabeth Ole A W OA Chen Binbin B Swaminathan Kavya K Rawson Keith K Liu Chih Long CL Steiner David D Lund Peder P Rao Samhita S Zhang Lichao L Marceau Caleb C Stehr Henning H Newman Aaron M AM Czerwinski Debra K DK Carlton Victoria E H VE Moorhead Martin M Faham Malek M Kohrt Holbrook E HE Carette Jan J Green Michael R MR Davis Mark M MM Levy Ronald R Elias Joshua E JE Alizadeh Ash A AA
Nature 20170322 7647
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge. Here we discover neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interrogates tumour antigen peptides presented by major histocompatibility complex (MHC) class I and class II molecules. We applied this approach to systematically characterize MHC ligand ...[more]