Proteomics

Dataset Information

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New Roles for Vitamin B12 Regulation

ABSTRACT: Elucidation of new roles for vitamin B12 in regulation of folate, ubiquinone, and methionine metabolism

INSTRUMENT(S):

ORGANISM(S): Environmental Samples Halomonas Sp. Hl-48

SUBMITTER: Matthew Monroe  

LAB HEAD: Aaron Wright

PROVIDER: PXD005723 | Pride | 2018-10-22

REPOSITORIES: Pride

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Dataset's files

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Action DRS
HL48_B12ABP_Inh_1_3Oct16_Frodo_16-05-17.mgf Mgf
HL48_B12ABP_Inh_1_3Oct16_Frodo_16-05-17.pride.mgf.gz Mgf
HL48_B12ABP_Inh_1_3Oct16_Frodo_16-05-17.raw Raw
HL48_B12ABP_Inh_1_3Oct16_Frodo_16-05-17_msgfplus.mzid.gz Mzid
HL48_B12ABP_Inh_1_3Oct16_Frodo_16-05-17_msgfplus.pride.mztab.gz Mztab
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Publications

Elucidation of roles for vitamin B<sub>12</sub> in regulation of folate, ubiquinone, and methionine metabolism.

Romine Margaret F MF   Rodionov Dmitry A DA   Maezato Yukari Y   Anderson Lindsey N LN   Nandhikonda Premchendar P   Rodionova Irina A IA   Carre Alexandre A   Li Xiaoqing X   Xu Chengdong C   Clauss Therese R W TR   Kim Young-Mo YM   Metz Thomas O TO   Wright Aaron T AT  

Proceedings of the National Academy of Sciences of the United States of America 20170130 7

Only a small fraction of vitamin B<sub>12</sub>-requiring organisms are able to synthesize B<sub>12</sub> de novo, making it a common commodity in microbial communities. Initially recognized as an enzyme cofactor of a few enzymes, recent studies have revealed additional B<sub>12</sub>-binding enzymes and regulatory roles for B<sub>12</sub> Here we report the development and use of a B<sub>12</sub>-based chemical probe to identify B<sub>12</sub>-binding proteins in a nonphototrophic B<sub>12</sub  ...[more]