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Discovery of potential early colorectal cancer biomarker

ABSTRACT: Differential analysis of proteomes originated from early lesion of colorectal cancer and colon control tissue using FFPE-FASPTM and Label free analysis using 2DnanoUPLC separation before analysis on a qTOF synapt HDMS G2 using ion mobility as supplementary separation dimension

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

DISEASE(S): Colon Cancer

SUBMITTER: Marie-Alice Meuwis

LAB HEAD: Edouard LOUIS

PROVIDER: PXD005735 | Pride | 2017-03-28

REPOSITORIES: Pride

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OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages.

Quesada-Calvo Florence F Massot Charlotte C Bertrand Virginie V Longuespée Rémi R Blétard Noëlla N Somja Joan J Mazzucchelli Gabriel G Smargiasso Nicolas N Baiwir Dominique D De Pauw-Gillet Marie-Claire MC Delvenne Philippe P Malaise Michel M Coimbra Marques Carla C Polus Marc M De Pauw Edwin E Meuwis Marie-Alice MA Louis Edouard E

Clinical proteomics 20170324

<h4>Background</h4>Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is important for reducing CRC incidence and increasing patient's survival.<h4>Methods</h4>We analysed 76 colorectal tissue samples originated from early CRC stages, normal or inflamed mucosa by <i>label</i>-<i>free proteomics</i>. The characterisation of three selected biomarke ...[more]

PMID: 28344541

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