Proteomics

Dataset Information

0

Quantitative proteome analysis of plasma microparticles for characterization of HCV-induced hepatic cirrhosis and hepatocellular carcinoma


ABSTRACT: A quantitative label-free proteome analysis was performed using plasma samples from 22 hepatitis-C virus (HCV)-induced liver cirrhosis patients, 16 HCV-positive hepatocellular carcinoma patients with underlying cirrhosis and 18 healthy controls. Plasma microparticles (PMPS) were isolated using ultracentrifugation and analyzed via label-free LC-MS/MS. A quantitative label-free proteome analysis was performed using plasma samples from 22 hepatitis-C virus (HCV)-induced liver cirrhosis patients, 16 HCV-positive hepatocellular carcinoma patients with underlying cirrhosis and 18 healthy controls. Plasma microparticles (PMPS) were isolated using ultracentrifugation and analyzed via label-free LC-MS/MS.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Liver Cirrhosis,Hepatitis C,Hepatocellular Carcinoma

SUBMITTER: Thilo Bracht  

LAB HEAD: Barbara Sitek

PROVIDER: PXD005777 | Pride | 2017-06-21

REPOSITORIES: Pride

altmetric image

Publications

Quantitative proteome analysis of plasma microparticles for the characterization of HCV-induced hepatic cirrhosis and hepatocellular carcinoma.

Taleb Raghda Saad Zaghloul RSZ   Moez Pacint P   Younan Doreen D   Eisenacher Martin M   Tenbusch Matthias M   Sitek Barbara B   Bracht Thilo T  

Proteomics. Clinical applications 20170710 11-12


<h4>Purpose</h4>Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor and a leading cause of cancer-related deaths worldwide. Cirrhosis induced by hepatitis-C virus (HCV) infection is the most critical risk factor for HCC. However, the mechanism of HCV-induced carcinogenesis is not fully understood. Plasma microparticles (PMP) contribute to numerous physiological and pathological processes and contain proteins whose composition correlates to the respective pathophysiolo  ...[more]

Similar Datasets

2020-03-12 | MSV000085094 | MassIVE
2015-03-30 | PXD001474 | Pride
2008-02-01 | GSE10356 | GEO
2005-11-19 | GSE3632 | GEO
2009-01-08 | GSE14323 | GEO
2023-03-11 | PXD024846 | Pride
| E-GEOD-61187 | biostudies-arrayexpress
2018-02-08 | GSE110312 | GEO
| E-GEOD-59492 | biostudies-arrayexpress
| E-GEOD-40744 | biostudies-arrayexpress