Proteomics

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Proteomic analysis of human anterior pituitary gland

ABSTRACT: The regulation of pituitary function via the hypothalamus and via intra-pituitary connections represents a complex system. Though hormones secreted from the pituitary glands have been well studied, overall information of proteins expressed in the pituitary glands is very limited. Protein expression profiling of normal pituitary tissue may lead to discovery of novel proteins playing an important role in the physiology of pituitary glands and can lead to better understanding of pituitary gland diseases. We aimed to carry out systematic proteomic profiling of adenohypophysis from human pituitary glands using high-resolution Fourier transform mass spectrometer. A total of 2,175 proteins were identified in this study of which, 105 proteins were identified for the first time as compared to high throughput proteomic-based studies from human pituitary glands. The comprehensive list of proteins identified in this study will facilitate the better understanding the role of this important gland in health and disease.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Adenohypophysis

SUBMITTER: Keshava Prasad T. S.  

LAB HEAD: T. S. Keshava Prasad

PROVIDER: PXD005819 | Pride | 2019-01-02

REPOSITORIES: Pride

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Proteomic Analysis of the Human Anterior Pituitary Gland.

Yelamanchi Soujanya D SD   Tyagi Ankur A   Mohanty Varshasnata V   Dutta Pinaki P   Korbonits Márta M   Chavan Sandip S   Advani Jayshree J   Madugundu Anil K AK   Dey Gourav G   Datta Keshava K KK   Rajyalakshmi M M   Sahasrabuddhe Nandini A NA   Chaturvedi Abhishek A   Kumar Amit A   Das Apabrita Ayan AA   Ghosh Dhiman D   Jogdand Gajendra M GM   Nair Haritha H HH   Saini Keshav K   Panchal Manoj M   Sarvaiya Mansi Ashwinsinh MA   Mohanraj Soundappan S SS   Sengupta Nabonita N   Saxena Priti P   Subramani Pradeep Annamalai PA   Kumar Pradeep P   Akkali Rakhil R   Reshma Saraswatipura Vishwabrahmachar SV   Santhosh Ramachandran Sarojini RS   Rastogi Sangita S   Kumar Sudarshan S   Ghosh Susanta Kumar SK   Irlapati Vamshi Krishna VK   Srinivasan Anand A   Radotra Bishan Das BD   Mathur Premendu P PP   Wong G William GW   Satishchandra Parthasarathy P   Chatterjee Aditi A   Gowda Harsha H   Bhansali Anil A   Pandey Akhilesh A   Shankar Susarla K SK   Mahadevan Anita A   Prasad T S Keshava TSK  

Omics : a journal of integrative biology 20181201 12

The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophy  ...[more]

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