Scanning Quadruople DIA - aspergillus fumigatus
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Xevo G2-S QTof
ORGANISM(S): Neosartorya Fumigata (aspergillus Fumigatus)
SUBMITTER: 
Hans Vissers
LAB HEAD: JPC Vissers
PROVIDER: PXD005848 | Pride | 2017-12-19
REPOSITORIES: Pride
Publications
Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs.
Juvvadi Praveen R PR Moseley M Arthur MA Hughes Christopher J CJ Soderblom Erik J EJ Lennon Sarah S Perkins Simon R SR Thompson J Will JW Geromanos Scott J SJ Wildgoose Jason J Richardson Keith K Langridge James I JI Vissers Johannes P C JPC Steinbach William J WJ
Journal of proteome research 20171229 2
Calcineurin is a critical cell-signaling protein that orchestrates growth, stress response, virulence, and antifungal drug resistance in several fungal pathogens. Blocking calcineurin signaling increases the efficacy of several currently available antifungals and suppresses drug resistance. We demonstrate the application of a novel scanning quadrupole DIA method for the analysis of changes in the proteins coimmunoprecipitated with calcineurin during therapeutic antifungal drug treatments of the ...[more]
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