Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human) Chlamydia Trachomatis
TISSUE(S): Cell Culture, Macrophage
DISEASE(S): Chlamydia Trachomatis Infectious Disease
SUBMITTER: James Wright
LAB HEAD: Jyoti Choudhary
PROVIDER: PXD005858 | Pride | 2018-02-14
REPOSITORIES: Pride
Yeung Amy T Y ATY Hale Christine C Lee Amy H AH Gill Erin E EE Bushell Wendy W Parry-Smith David D Goulding David D Pickard Derek D Roumeliotis Theodoros T Choudhary Jyoti J Thomson Nick N Skarnes William C WC Dougan Gordon G Hancock Robert E W REW
Nature communications 20170425
Chlamydia trachomatis remains a leading cause of bacterial sexually transmitted infections and preventable blindness worldwide. There are, however, limited in vitro models to study the role of host genetics in the response of macrophages to this obligate human pathogen. Here, we describe an approach using macrophages derived from human induced pluripotent stem cells (iPSdMs) to study macrophage-Chlamydia interactions in vitro. We show that iPSdMs support the full infectious life cycle of C. trac ...[more]