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Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression

ABSTRACT: Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

DISEASE(S): Breast Cancer

SUBMITTER: Florian Christoph Sigloch

LAB HEAD: Oliver Schilling

PROVIDER: PXD005860 | Pride | 2017-12-04

REPOSITORIES: Pride

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Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression.

Sigloch Florian Christoph FC Tholen Martina M Gomez-Auli Alejandro A Biniossek Martin Lothar ML Reinheckel Thomas T Schilling Oliver O

Journal of Cancer 20171023 19

Studies in the MMTV-PyMT (PyMT) breast cancer mouse model have shown a strong influence of the lysosomal cysteine cathepsins B or L on lung metastasis formation. Transgenic expression of human <i>CTSB</i> (tgCTSB) or <i>CTSL</i> (tgCTSL) both led to similar metastatic phenotypes with increased metastatic burden in the PyMT mice. However, recent studies in other tumor models proved marked differences in effects of either cathepsin on the proteome composition. We sought to analyze and compare prot ...[more]

PMID: 29187882

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