Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human) Human Cytomegalovirus (hhv-5) (human Herpesvirus 5)
TISSUE(S): Cell Culture, Fibroblast
DISEASE(S): Cytomegalovirus Retinitis
SUBMITTER: Yagnesh Umrania
LAB HEAD: Michael Weekes
PROVIDER: PXD005883 | Pride | 2017-02-14
REPOSITORIES: Pride
Fielding Ceri A CA Weekes Michael P MP Nobre Luis V LV Ruckova Eva E Wilkie Gavin S GS Paulo Joao A JA Chang Chiwen C Suárez Nicolás M NM Davies James A JA Antrobus Robin R Stanton Richard J RJ Aicheler Rebecca J RJ Nichols Hester H Vojtesek Borek B Trowsdale John J Davison Andrew J AJ Gygi Steven P SP Tomasec Peter P Lehner Paul J PJ Wilkinson Gavin W G GW
eLife 20170210
The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel natural killer (NK) cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1300 cell surface and ~7200 whole cell proteins, we demonstrate that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecu ...[more]