Proteomics

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Proteomic landscape of the primary somatosensory cortex upon sensory deprivation

ABSTRACT: We employed label free quantitative mass spectrometry to address experience-dependent changes in the proteome after sensory deprivation in the primary somatosensory cortex. Cortical column- and layer-specific tissue samples were collected from control animals, with all whiskers intact, and animals whose C-row whiskers were bilaterally plucked for 11-14 days.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Rik Lindeboom  

LAB HEAD: Michiel Vermeulen

PROVIDER: PXD005971 | Pride | 2017-08-24

REPOSITORIES: Pride

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Proteomic landscape of the primary somatosensory cortex upon sensory deprivation.

Kole Koen K   Lindeboom Rik G H RGH   Baltissen Marijke P A MPA   Jansen Pascal W T C PWTC   Vermeulen Michiel M   Tiesinga Paul P   Celikel Tansu T  

GigaScience 20171001 10

Experience-dependent plasticity (EDP) powerfully shapes neural circuits by inducing long-lasting molecular changes in the brain. Molecular mechanisms of EDP have been traditionally studied by identifying single or small subsets of targets along the biochemical pathways that link synaptic receptors to nuclear processes. Recent technological advances in large-scale analysis of gene transcription and translation now allow systematic observation of thousands of molecules simultaneously. Here we empl  ...[more]

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