SILAC analysis of relative protein abundance in nuclei - PRF168 and PRF167

ABSTRACT: Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectrometry to investigate nuclear protein abundance in primary HGPS-derived cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Fibroblast

DISEASE(S): Progeria

SUBMITTER: Abby Buchwalter  

LAB HEAD: Martin W. Hetzer

PROVIDER: PXD006013 | Pride | 2017-07-07

REPOSITORIES: Pride