SILAC analysis of relative protein abundance in nuclei - PRF168 and PRF167
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ABSTRACT: Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectrometry to investigate nuclear protein abundance in primary HGPS-derived cells.
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Fibroblast
DISEASE(S): Progeria
SUBMITTER: Abby Buchwalter
LAB HEAD: Martin W. Hetzer
PROVIDER: PXD006013 | Pride | 2017-07-07
REPOSITORIES: Pride
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