SILAC pulse labeling in HGPS fibroblasts - WT samples

ABSTRACT: Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectrometry to investigate nuclear protein homeostasis in primary HGPS-derived cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Fibroblast

DISEASE(S): Progeria

SUBMITTER: Abby Buchwalter  

LAB HEAD: Martin W. Hetzer

PROVIDER: PXD006015 | Pride | 2017-07-07

REPOSITORIES: Pride