Proteomics

Dataset Information

15

Multi-omics analysis of β-catenin oncogenic networks


ABSTRACT: We used interaction and expression proteomic techniques in conjunction with RNA-Seq transcriptomic analysis to analyse how a β-catenin stabilizing mutation alters molecular networks in colorectal cancer cells. Integrated computational analyses of allowed us to identify significantly altered sub-networks linked to β-catenin oncogenesis.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo sapiens  

TISSUE(S): Cell Culture

DISEASE(S): Colon Cancer

SUBMITTER: Rob Ewing  

PROVIDER: PXD006053 | Pride | 2018-05-18

REPOSITORIES: Pride

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Publications

Multiproteomic and Transcriptomic Analysis of Oncogenic β-Catenin Molecular Networks.

Ewing Rob M RM   Song Jing J   Gokulrangan Giridharan G   Bai Sheldon S   Bowler Emily H EH   Bolton Rachel R   Skipp Paul P   Wang Yihua Y   Wang Zhenghe Z  

Journal of proteome research 20180518 6


The dysregulation of Wnt signaling is a frequent occurrence in many different cancers. Oncogenic mutations of CTNNB1/β-catenin, the key nuclear effector of canonical Wnt signaling, lead to the accumulation and stabilization of β-catenin protein with diverse effects in cancer cells. Although the transcriptional response to Wnt/β-catenin signaling activation has been widely studied, an integrated understanding of the effects of oncogenic β-catenin on molecular networks is lacking. We used affinity  ...[more]

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