Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA408128GSE104059
INSTRUMENT(S): LTQ Orbitrap Velos, LTQ
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Embryo, Cell Culture
SUBMITTER: Barry Zee
LAB HEAD: Mitzi Kuroda
PROVIDER: PXD006079 | Pride | 2017-11-02
REPOSITORIES: Pride
Kang Hyuckjoon H Jung Youngsook L YL McElroy Kyle A KA Zee Barry M BM Wallace Heather A HA Woolnough Jessica L JL Park Peter J PJ Kuroda Mitzi I MI
Genes & development 20171025 19
Regulatory decisions in <i>Drosophila</i> require Polycomb group (PcG) proteins to maintain the silent state and Trithorax group (TrxG) proteins to oppose silencing. Since PcG and TrxG are ubiquitous and lack apparent sequence specificity, a long-standing model is that targeting occurs via protein interactions; for instance, between repressors and PcG proteins. Instead, we found that Pc-repressive complex 1 (PRC1) purifies with coactivators Fs(1)h [female sterile (1) homeotic] and Enok/Br140 dur ...[more]