Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap XL
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Bone
DISEASE(S): Osteosarcoma
SUBMITTER: Nicolas Nalpas
LAB HEAD: Tassula Proikas-Cezanne
PROVIDER: PXD006119 | Pride | 2017-06-01
REPOSITORIES: Pride
Bakula Daniela D Müller Amelie J AJ Zuleger Theresia T Takacs Zsuzsanna Z Franz-Wachtel Mirita M Thost Ann-Katrin AK Brigger Daniel D Tschan Mario P MP Frickey Tancred T Robenek Horst H Macek Boris B Proikas-Cezanne Tassula T
Nature communications 20170531
Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control the production of phosphatidylinositol 3-phosphate (PtdIns3P), a prerequisite for autophagosome formation. Here we report that WIPI3 and WIPI4 scaffold the signal control of autophagy upstream of PtdIns3P production and have a role in the PtdIns3P effector function of WIPI1-WIPI2 at nascent autophagosomes. In response to LKB1-mediated AMPK stimulation, WIPI4-ATG2 is released from a WIPI4-ATG2/AMPK-ULK1 comple ...[more]