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Proteomics on post-mortem human brain tissue of patients with Alzheimer`s, Parkinson`s and Lewy body dementias.

ABSTRACT: We have used HiRIEF (High Resolution Isoelectric Focusing) LC-MS proteomics with isobaric tags (TMT10plex) to compare 32 post-mortem human brains in the prefrontal cortex (Brodmann area 9) of prospectively followed patients with Alzheimer`s disease (AD), Parkinson`s disease with dementia (PDD), dementia with Lewy bodies (DLB) and older adults without dementia.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Lewy Body Dementia,Parkinson's Disease,Alzheimer's Disease

SUBMITTER: Rui Branca

LAB HEAD: Janne Lehtiö

PROVIDER: PXD006122 | Pride | 2017-12-08

REPOSITORIES: Pride

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Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach.

Bereczki Erika E Branca Rui M RM Francis Paul T PT Pereira Joana B JB Baek Jean-Ha JH Hortobágyi Tibor T Winblad Bengt B Ballard Clive C Lehtiö Janne J Aarsland Dag D

Brain : a journal of neurology 20180201 2

See Attems and Jellinger (doi:10.1093/brain/awx360) for a scientific commentary on this article.Cognitive changes occurring throughout the pathogenesis of neurodegenerative diseases are directly linked to synaptic loss. We used in-depth proteomics to compare 32 post-mortem human brains in the prefrontal cortex of prospectively followed patients with Alzheimer's disease, Parkinson's disease with dementia, dementia with Lewy bodies and older adults without dementia. In total, we identified 10 325 ...[more]

PMID: 29324989

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