Dataset Information


Fiber-associated microbiota protects against diet-induced amelioration of the colonic mucus barrier

ABSTRACT: Here we have shown that diet-mediated alterations of the gut microbiota composition cause an erosion of the colonic mucus barrier. A compensatory increase in cellular mucus production by the host is not sufficient to re-establish the barrier, possibly due to a lacking increase in mucus secretion. While microbial transplant from mice fed a fiber-rich diet can prevent the mucus defects, the mechanism seems to be independent of general fiber fermentation and rather depend on distinct bacterial species and/or their metabolites.


ORGANISM(S): Mus musculus  

TISSUE(S): Colon, Colonic Mucosa

DISEASE(S): Not Available

SUBMITTER: Liisa Arike  

PROVIDER: PXD006129 | Pride | 2017-12-22


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Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration.

Schroeder Bjoern O BO   Birchenough George M H GMH   Ståhlman Marcus M   Arike Liisa L   Johansson Malin E V MEV   Hansson Gunnar C GC   Bäckhed Fredrik F  

Cell host & microbe 20171221 1

Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut bacteria from the host. However, the interplay between a Western style diet (WSD), gut microbiota composition, and the intestinal mucus layer is less clear. Here we show that mice fed a WSD have an altered colonic microbiota composition that causes increased penetrability and a reduced growth rate of the inner mucus layer. Both barrier defec  ...[more]

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