Fiber-associated microbiota protects against diet-induced amelioration of the colonic mucus barrier

ABSTRACT: Here we have shown that diet-mediated alterations of the gut microbiota composition cause an erosion of the colonic mucus barrier. A compensatory increase in cellular mucus production by the host is not sufficient to re-establish the barrier, possibly due to a lacking increase in mucus secretion. While microbial transplant from mice fed a fiber-rich diet can prevent the mucus defects, the mechanism seems to be independent of general fiber fermentation and rather depend on distinct bacterial species and/or their metabolites.

OTHER RELATED OMICS DATASETS IN: PRJEB20367

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Colon, Colonic Mucosa

SUBMITTER: Liisa Arike  

LAB HEAD: Liisa Arike

PROVIDER: PXD006129 | Pride | 2017-12-22

REPOSITORIES: pride