Proteomics

Dataset Information

48

Fiber-associated microbiota protects against diet-induced amelioration of the colonic mucus barrier


ABSTRACT: Here we have shown that diet-mediated alterations of the gut microbiota composition cause an erosion of the colonic mucus barrier. A compensatory increase in cellular mucus production by the host is not sufficient to re-establish the barrier, possibly due to a lacking increase in mucus secretion. While microbial transplant from mice fed a fiber-rich diet can prevent the mucus defects, the mechanism seems to be independent of general fiber fermentation and rather depend on distinct bacterial species and/or their metabolites.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus musculus  

TISSUE(S): Colon, Colonic Mucosa

DISEASE(S): Not Available

SUBMITTER: Liisa Arike  

PROVIDER: PXD006129 | Pride | 2017-12-22

REPOSITORIES: Pride

altmetric image

Publications

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration.

Schroeder Bjoern O BO   Birchenough George M H GMH   Ståhlman Marcus M   Arike Liisa L   Johansson Malin E V MEV   Hansson Gunnar C GC   Bäckhed Fredrik F  

Cell host & microbe 20171221 1


Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut bacteria from the host. However, the interplay between a Western style diet (WSD), gut microbiota composition, and the intestinal mucus layer is less clear. Here we show that mice fed a WSD have an altered colonic microbiota composition that causes increased penetrability and a reduced growth rate of the inner mucus layer. Both barrier defec  ...[more]

Similar Datasets

| GSE79067 | GEO
2018-10-22 | PXD006770 | Pride
| PRJEB20367 | ENA
| GSE97504 | GEO
2015-02-09 | PXD001479 | Pride
2013-01-30 | E-GEOD-43917 | ArrayExpress
2008-04-25 | E-GEOD-11254 | ArrayExpress
2018-10-24 | PXD006183 | Pride
2015-08-03 | E-GEOD-40670 | ArrayExpress
| GSE70950 | GEO