Name: RIME against PBX1 protein in P19.6 mouse embryonal carcinoma cells treated for 48 hours with all-trans retinoic acid
Keywords: Pbx1

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RIME against PBX1 protein in P19.6 mouse embryonal carcinoma cells treated for 48 hours with all-trans retinoic acid

ABSTRACT: Identification of PBX1 interactors in P19.6 mouse embryonal carcinoma cells treated for 48 hours with all-trans retinoic acid.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Early Embryonic Cell

SUBMITTER: Aurelien Serandour

LAB HEAD: Gilles Salbert

PROVIDER: PXD006158 | Pride | 2017-04-03

REPOSITORIES: Pride

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Cytosine modifications modulate the chromatin architecture of transcriptional enhancers.

Mahé Elise A EA Madigou Thierry T Sérandour Aurélien A AA Bizot Maud M Avner Stéphane S Chalmel Frédéric F Palierne Gaëlle G Métivier Raphaël R Salbert Gilles G

Genome research 20170410 6

Epigenetic mechanisms are believed to play key roles in the establishment of cell-specific transcription programs. Accordingly, the modified bases 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have been observed in DNA of genomic regulatory regions such as enhancers, and oxidation of 5mC into 5hmC by Ten-eleven translocation (TET) proteins correlates with enhancer activation. However, the functional relationship between cytosine modifications and the chromatin architecture of enhance ...[more]

PMID: 28396520

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