Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hela Cell
SUBMITTER: Christian Poitras
LAB HEAD: Benoit Coulombe
PROVIDER: PXD006199 | Pride | 2017-11-02
REPOSITORIES: Pride
Cloutier Philippe P Poitras Christian C Durand Mathieu M Hekmat Omid O Fiola-Masson Émilie É Bouchard Annie A Faubert Denis D Chabot Benoit B Coulombe Benoit B
Nature communications 20170531
The R2TP/Prefoldin-like (R2TP/PFDL) complex has emerged as a cochaperone complex involved in the assembly of a number of critical protein complexes including snoRNPs, nuclear RNA polymerases and PIKK-containing complexes. Here we report on the use of multiple target affinity purification coupled to mass spectrometry to identify two additional complexes that interact with R2TP/PFDL: the TSC1-TSC2 complex and the U5 small nuclear ribonucleoprotein (snRNP). The interaction between R2TP/PFDL and the ...[more]