Proteomics

Dataset Information

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NHBE proteome response to a wild type infectious clone of H1N1 Influenza virus

ABSTRACT: Proteomic data from mouse lung; Treated with wild-type and mutant H7N9 and mockulum; Time points 1, 2, 4 & 7 days; 5 biological replicates

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung, Epithelial Cell Of Lung

DISEASE(S): Influenza

SUBMITTER: Matthew Monroe  

LAB HEAD: Heather S. Smallwood

PROVIDER: PXD006265 | Pride | 2017-05-24

REPOSITORIES: Pride

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Publications

Influenza is a worldwide health and financial burden posing a significant risk to the immune-compromised, obese, diabetic, elderly, and pediatric populations. We identified increases in glucose metabolism in the lungs of pediatric patients infected with respiratory pathogens. Using quantitative mass spectrometry, we found metabolic changes occurring after influenza infection in primary human respiratory cells and validated infection-associated increases in c-Myc, glycolysis, and glutaminolysis.  ...[more]

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