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ITRAQ-based quantitative proteome of HHD biopsies

ABSTRACT: the proteome of skin lesions from HHD patients was assembled and used for iTRAQ to analyze changes in skin lesions compared with unaffected individuals.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skin

SUBMITTER: Xiaoli Li

LAB HEAD: Xiaoli Li

PROVIDER: PXD006286 | Pride | 2018-12-10

REPOSITORIES: Pride

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Altered levels of focal adhesion and extracellular matrix-receptor interacting proteins were identified in Hailey-Hailey disease by quantitative iTRAQ proteome analysis.

Zhang Dingwei D Huo Jia J Li Ruilian R Zhang Yanfei Y Wang Zhenghui Z Li Xiaoli X

Journal of cellular biochemistry 20181203 3

Benign chronic familial pemphigus or Hailey-Hailey disease (HHD, OMIM 169600) is a rare, autosomal dominant blistering skin disorder characterized by suprabasal cell separation (acantholysis) of the epidermis. To date, the proteomic changes in skin lesions from HHD patients has not been reported yet. In this study, a sample of skin lesions from HHD patients was collected for isobaric tags for relative and absolute quantitation to analyze proteome changes compared with unaffected individuals. The ...[more]

PMID: 30506709

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