Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
DISEASE(S): Parkinson's Disease
SUBMITTER: Timothy Shaw
LAB HEAD: Junmin Peng
PROVIDER: PXD006290 | Pride | 2018-05-03
REPOSITORIES: Pride
Kozina Elena E Sadasivan Shankar S Jiao Yun Y Dou Yuchen Y Ma Zhijun Z Tan Haiyan H Kodali Kiran K Shaw Timothy T Peng Junmin J Smeyne Richard J RJ
Brain : a journal of neurology 20180601 6
Missense mutations in the leucine rich repeat kinase 2 (LRRK2) gene result in late-onset Parkinson's disease. The incomplete penetrance of LRRK2 mutations in humans and LRRK2 murine models of Parkinson's disease suggests that the disease may result from a complex interplay of genetic predispositions and persistent exogenous insults. Since neuroinflammation is commonly associated with the pathogenesis of Parkinson's disease, we examine a potential role of mutant LRRK2 in regulation of the immune ...[more]