Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA330691
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line
SUBMITTER: Miguel Prado
LAB HEAD: Daniel J Finley
PROVIDER: PXD006293 | Pride | 2017-06-01
REPOSITORIES: Pride
Quirós Pedro M PM Prado Miguel A MA Zamboni Nicola N D'Amico Davide D Williams Robert W RW Finley Daniel D Gygi Steven P SP Auwerx Johan J
The Journal of cell biology 20170531 7
Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt cellular metabolism to stress. Using a multiomics approach in mammalian cells treated with four types of mitochondrial stressors, we identify activating transcription factor 4 (ATF4) as the main regulator of the stress response. Surprisingly, canonical mitochondrial unfolded protein response genes mediated by ATF5 are not activated. Instead, ATF4 activates the expression of cytoprote ...[more]