Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Sabine Cuijpers
LAB HEAD: Alfred C.O. Vertegaal
PROVIDER: PXD006335 | Pride | 2018-09-19
REPOSITORIES: Pride
Eifler Karolin K Cuijpers Sabine A G SAG Willemstein Edwin E Raaijmakers Jonne A JA El Atmioui Dris D Ovaa Huib H Medema René H RH Vertegaal Alfred C O ACO
Nature communications 20180316 1
Signal transduction by small ubiquitin-like modifier (SUMO) regulates a myriad of nuclear processes. Here we report on the role of SUMO in mitosis in human cell lines. Knocking down the SUMO conjugation machinery results in a delay in mitosis and defects in mitotic chromosome separation. Searching for relevant SUMOylated proteins in mitosis, we identify the anaphase-promoting complex/cyclosome (APC/C), a master regulator of metaphase to anaphase transition. The APC4 subunit is the major SUMO tar ...[more]