Proteomics

Dataset Information

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Human colon aspirate proteins analyzed by LC-MSMS


ABSTRACT: Colonic aspirates were collected at diagnostic colonoscopy from inflammatory bowel disease (IBD) and control, treatment-naive children. The colonic mucosal-luminal interface (MLI) proteomes were analyzed for 18 control and 42 IBD patients by liquid-chromatography mass spectrometry.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

SUBMITTER: Shelley Deeke  

LAB HEAD: Daniel Figeys

PROVIDER: PXD006383 | Pride | 2018-03-19

REPOSITORIES: Pride

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Publications

Mucosal-luminal interface proteomics reveals biomarkers of pediatric inflammatory bowel disease-associated colitis.

Deeke Shelley A SA   Starr Amanda E AE   Ning Zhibin Z   Ahmadi Sara S   Zhang Xu X   Mayne Janice J   Chiang Cheng-Kang CK   Singleton Ruth R   Benchimol Eric I EI   Mack David R DR   Stintzi Alain A   Figeys Daniel D  

The American journal of gastroenterology 20180312 5


<h4>Objective</h4>Improved biomarkers are an unmet clinical need for suspected inflammatory bowel disease (IBD). Need is greatest for children, since current biomarkers suffers from low specificity, particularly in this population; thus, invasive testing methods, with the accompanying risk of complications, are necessary. Additionally, current biomarkers do not delineate disease extent assessment for ulcerative colitis (UC), a factor involved in therapeutic decisions.<h4>Methods</h4>Intestinal m  ...[more]

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