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Mus_Oocytes _LC-MS/MS - Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice

ABSTRACT: A quantitative mass-spectrometry-based proteome profiles of oocytes

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Oocyte

SUBMITTER: hao zhang

LAB HEAD: Xuejiang Guo

PROVIDER: PXD006408 | Pride | 2018-10-24

REPOSITORIES: Pride

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Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice.

Guo Jing J Zhang Teng T Guo Yueshuai Y Sun Tao T Li Hui H Zhang Xiaoyun X Yin Hong H Cao Guangyi G Yin Yaoxue Y Wang Hao H Shi Lanying L Guo Xuejiang X Sha Jiahao J Eppig John J JJ Su You-Qiang YQ

Proceedings of the National Academy of Sciences of the United States of America 20180521 23

MTOR (mechanistic target of rapamycin) is a widely recognized integrator of signals and pathways key for cellular metabolism, proliferation, and differentiation. Here we show that conditional knockout (cKO) of <i>Mtor</i> in either primordial or growing oocytes caused infertility but differentially affected oocyte quality, granulosa cell fate, and follicular development. cKO of <i>Mtor</i> in nongrowing primordial oocytes caused defective follicular development leading to progressive degeneratio ...[more]

PMID: 29784807

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