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PPT1 binding proteins - The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function

ABSTRACT: Binding of proteins from mouse brain lysates to GFP-PPT1

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Karin Hansson

LAB HEAD: Peter James

PROVIDER: PXD006429 | Pride | 2019-11-08

REPOSITORIES: Pride

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The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function.

Sapir Tamar T Segal Michal M Grigoryan Gayane G Hansson Karin M KM James Peter P Segal Menahem M Reiner Orly O

Frontiers in cellular neuroscience 20190313

Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include progressive neurodegeneration and blindness, as well as seizures. In the current study, we identified 62 high-confident PPT1-binding proteins. These proteins included a self-interaction of PPT1, two V-type ATPases, calcium voltage-gated channels, cytoskeletal proteins and others. Pathway analysis suggested their involvement in ...[more]

PMID: 30918483

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