Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: MTBLS183
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Breast Epithelium, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Tamar Geiger
LAB HEAD: Tamar Geiger
PROVIDER: PXD006449 | Pride | 2020-05-26
REPOSITORIES: Pride
Katzir Rotem R Polat Ibrahim H IH Harel Michal M Katz Shir S Foguet Carles C Selivanov Vitaly A VA Sabatier Philippe P Cascante Marta M Geiger Tamar T Ruppin Eytan E
Scientific reports 20191128 1
Altered metabolism is a hallmark of cancer, but little is still known about its regulation. In this study, we measure transcriptomic, proteomic, phospho-proteomic and fluxomics data in a breast cancer cell-line (MCF7) across three different growth conditions. Integrating these multiomics data within a genome scale human metabolic model in combination with machine learning, we systematically chart the different layers of metabolic regulation in breast cancer cells, predicting which enzymes and pa ...[more]