Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Claudio Ponte de Albuquerque
LAB HEAD: Paul S. Mischel3
PROVIDER: PXD006461 | Pride | 2017-06-28
REPOSITORIES: Pride
Gu Yuchao Y Albuquerque Claudio P CP Braas Daniel D Zhang Wei W Villa Genaro R GR Bi Junfeng J Ikegami Shiro S Masui Kenta K Gini Beatrice B Yang Huijun H Gahman Timothy C TC Shiau Andrew K AK Cloughesy Timothy F TF Christofk Heather R HR Zhou Huilin H Guan Kun-Liang KL Mischel Paul S PS
Molecular cell 20170622 1
Mutations in cancer reprogram amino acid metabolism to drive tumor growth, but the molecular mechanisms are not well understood. Using an unbiased proteomic screen, we identified mTORC2 as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate antiporter xCT. mTORC2 phosphorylates serine 26 at the cytosolic N terminus of xCT, inhibiting its activity. Genetic inhibition of mTORC2, or pharmacologic inhibition of the mammalian target of rapamycin (mTOR) ...[more]