Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mycobacterium Avium Complex Mycobacterium Avium Subsp. Hominissuis
SUBMITTER: Jayaseelan Murugaiyan
LAB HEAD: Jayaseelan Murugaiyan
PROVIDER: PXD006470 | Pride | 2018-02-26
REPOSITORIES: Pride
Kirubakar Greana G Murugaiyan Jayaseelan J Schaudinn Christoph C Dematheis Flavia F Holland Gudrun G Eravci Murat M Weise Christoph C Roesler Uwe U Lewin Astrid A
The Journal of infectious diseases 20180601 2
Lysyl-phosphatidylglycerol is one of the components of the mycobacterial membrane that contributes to the resistance to cationic antimicrobial peptides, a host-induced frontline defense against invading pathogens. Its production is catalyzed by LysX, a bifunctional protein with lysyl transferase and lysyl transfer RNA synthetase activity. Comparative proteome analysis of a lysX mutant of Mycobacterium avium strain 104 and the wild type indicated that the lysX mutant strain undergoes a transition ...[more]