Essential proteins' dynamics in Streptococcus sanguinis under antibiotic effect.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Streptococcus Sanguinis Sk36
TISSUE(S): Prokaryotic Cell, Cell Suspension Culture
DISEASE(S): Infective Endocarditis
SUBMITTER: 
Fadi El-Rami
LAB HEAD: Ping Xu
PROVIDER: PXD006479 | Pride | 2018-01-09
REPOSITORIES: Pride
Publications
Analysis of essential gene dynamics under antibiotic stress in Streptococcus sanguinis.
El-Rami Fadi F Kong Xiangzhen X Parikh Hardik H Zhu Bin B Stone Victoria V Kitten Todd T Xu Ping P
Microbiology (Reading, England) 20180201 2
The paradoxical response of Streptococcus sanguinis to drugs prescribed for dental and clinical practices has complicated treatment guidelines and raised the need for further investigation. We conducted a high throughput study on concomitant transcriptome and proteome dynamics in a time course to assess S. sanguinis behaviour under a sub-inhibitory concentration of ampicillin. Temporal changes at the transcriptome and proteome level were monitored to cover essential genes and proteins over a phy ...[more]
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