Dataset Information
Unrestricted analysis of modifications in proteins exposed to metal-catalyzed oxidation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human) Bos Taurus (bovine)
TISSUE(S): Blood Serum
SUBMITTER: 
Per Hägglund
LAB HEAD: Per Hägglund
PROVIDER: PXD006582 | Pride | 2017-09-21
REPOSITORIES: Pride
Publications
Unrestricted Mass Spectrometric Data Analysis for Identification, Localization, and Quantification of Oxidative Protein Modifications.
Journal of proteome research 20170929 11
Oxidation generates multiple diverse post-translational modifications resulting in changes in protein structure and function associated with a wide range of diseases. Of these modifications, carbonylations have often been used as hallmarks of oxidative damage. However, accumulating evidence supports the hypothesis that other oxidation products may be quantitatively more important under physiological conditions. To address this issue, we have developed a holistic mass spectrometry-based approach ...[more]
