Dataset Information
Proteome profiling - Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Linhui Zhai
LAB HEAD: linhui
PROVIDER: PXD006602 | Pride | 2018-06-06
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| MaxQuant_Output.zip | Other | |||
| SILAC_profiling_20161214_10_F1.raw | Raw | |||
| SILAC_profiling_20161214_10_F2.raw | Raw | |||
| SILAC_profiling_20161214_10_F3.raw | Raw | |||
| SILAC_profiling_20161214_10_F4.raw | Raw |
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Publications
Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death.
Cell research 20180528 6
Cellular senescence is a fundamental cell fate playing a significant role throughout the natural aging process. However, the molecular determinants distinguishing senescence from other cell-cycle arrest states such as quiescence and post-mitotic state, and the specified mechanisms underlying cell-fate decisions towards senescence versus cell death in response to cellular stress stimuli remain less understood. Employing multi-omics approaches, we revealed that switching off the specific mitochond ...[more]
