Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA388462
INSTRUMENT(S): Bruker Daltonics instrument model
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Jenny Moon
LAB HEAD: Leonard J. Foster
PROVIDER: PXD006613 | Pride | 2017-07-07
REPOSITORIES: Pride
Cell reports 20170701 2
The causal relationships between insulin levels, insulin resistance, and longevity are not fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling components can extend invertebrate and mammalian lifespan, but insulin resistance, a natural form of decreased insulin signaling, is associated with greater risk of age-related disease in mammals. We compared Ins2<sup>+/-</sup> mice to Ins2<sup>+/+</sup> littermate controls, on a genetically stable Ins1 null b ...[more]